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UltraFlora® Night Rest & Digest Postbiotic

Dual-Action Postbiotic for Nighttime Digestive & Sleep Support Without Melatonin

Digestion & Probiotics
Essential Wellness
Supports digestion, gut comfort, and restful sleep while you rest. Designed for nighttime use to help ease bloating, belching, and digestive discomfort while supporting the gut brain axis.

Select Container Size

Why youll love UltraFlora® Night Rest & Digest

UltraFlora® Night Rest & Digest formula combines clinically studied digestive enzymes, a postbiotic, and botanicals — without melatonin. This dual action formula is designed to help you:

  • Wake up feeling light and comfortable, not bloated or sluggish*
  • Support digestion while you sleep, not just after meals*
  • Ease the nighttime digestive discomfort that keeps you awake*
  • Support restful sleep through the gut-brain axis — no melatonin required*
  • Build a consistent nighttime routine that works while you rest

The Science Inside

This dual action postbiotic formula combines clinically studied digestive enzymes, a postbiotic strain, and targeted botanicals to support your gut and sleep from multiple angles.

  • Asafin®: an extract from the Hing plant shown to reduce bloating, burning, and digestive discomfort
  • Poolzyme®: a blend of 5 digestive enzymes that help break down food for easier digestion
  • Bifidobaterium longum (ES1): a postbiotic strain that supports a healthy microbiome & gut-brain connection
  • Milk Thistle: a botanical extract to help support liver function and natural detox process

Together, these ingredients support comfortable overnight digestion, relief from occasional indigestion, and better sleep through the gut-brain connection. *


Third party tested. Practitioner trusted.

For over 40 years, Metagenics® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:

  • Produced in GMP and NSF-certified facilities to meet the highest quality standards.
  • Science-backed: We perform +200K tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
  • Third-party Tested: All our products are independently verified for purity, potency, & safety.
  • Metagenics® is the #1 Doctor-Recommended Professional Supplement Brand trusted by 50,000 healthcare practitioners.
  • Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly and with purpose.
  • Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee.

Allergen Information

Non-GMO | Gluten-free | Dairy-free | Sugar-free | Allergen-free | No fillers | No preservatives | Vegetarian

IngredientAmount Per Serving% Daily Value
Serving Size1 Capsule†
Servings Per Container14
Asafetida oleo-gum-resin extract††250 mg**
A Proprietary Enzyme Blend of: Lactase, Protease, Amylase, Lipase & Cellulase200 mg**
Milk thistle (Silybum marianum) seed extract80 mg**
Heat-treated Bifidobacterium longum subsp. longum CECT7347 (ES1)25 mg**
**Daily Value not established.

Other Ingredients: Capsule [hydroxypropylmethylcellulose, water, sorbitol, silicon dioxide, and sodium copper chlorophyllin (color)], microcrystalline cellulose, magnesium stearate (vegetable), and silicon dioxide.

Take one capsule daily with the evening meal. A second capsule may be taken with a separate main meal, if needed or as directed by a healthcare practitioner.

Dry Place

  • Discontinue use and consult your healthcare practitioner if stomach discomfort occurs following administration. Do not use if you have a current peptic

  • or duodenal ulcer. Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If you are taking anti-diabetic medications, consult your healthcare practitioner before use. Keep out of the reach of children.

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A graphic explaining the gut–sleep connection, featuring a green illustration of the digestive system labeled “gut‑brain axis” alongside text about indigestion disrupting sleep and how UltraFlora® Night Rest & Digest supports gut‑brain health.
A person sleeping peacefully next to icons for bloating, fullness, belching, burning, and post‑meal discomfort, with text highlighting how nighttime digestive support can reduce overnight disturbances for better sleep.
A hand holding a capsule surrounded by icons representing product benefits, with text emphasizing better digestion for better sleep, no melatonin or antacids, and the formula’s probiotic, enzymes, and digestive adaptogen for nighttime comfort and relaxation.
A bottle of UltraFlora® Night Rest & Digest Postbiotic with green arrows pointing to listed results, including improvements in gut microbiome balance, cognitive tasks, bloating, and dyspepsia symptoms after two weeks.
Digestion & Probiotics
Essential Wellness
Supports digestion, gut comfort, and restful sleep while you rest. Designed for nighttime use to help ease bloating, belching, and digestive discomfort while supporting the gut brain axis.

Select Container Size

Why youll love UltraFlora® Night Rest & Digest

UltraFlora® Night Rest & Digest formula combines clinically studied digestive enzymes, a postbiotic, and botanicals — without melatonin. This dual action formula is designed to help you:

  • Wake up feeling light and comfortable, not bloated or sluggish*
  • Support digestion while you sleep, not just after meals*
  • Ease the nighttime digestive discomfort that keeps you awake*
  • Support restful sleep through the gut-brain axis — no melatonin required*
  • Build a consistent nighttime routine that works while you rest

The Science Inside

This dual action postbiotic formula combines clinically studied digestive enzymes, a postbiotic strain, and targeted botanicals to support your gut and sleep from multiple angles.

  • Asafin®: an extract from the Hing plant shown to reduce bloating, burning, and digestive discomfort
  • Poolzyme®: a blend of 5 digestive enzymes that help break down food for easier digestion
  • Bifidobaterium longum (ES1): a postbiotic strain that supports a healthy microbiome & gut-brain connection
  • Milk Thistle: a botanical extract to help support liver function and natural detox process

Together, these ingredients support comfortable overnight digestion, relief from occasional indigestion, and better sleep through the gut-brain connection. *


Third party tested. Practitioner trusted.

For over 40 years, Metagenics® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:

  • Produced in GMP and NSF-certified facilities to meet the highest quality standards.
  • Science-backed: We perform +200K tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
  • Third-party Tested: All our products are independently verified for purity, potency, & safety.
  • Metagenics® is the #1 Doctor-Recommended Professional Supplement Brand trusted by 50,000 healthcare practitioners.
  • Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly and with purpose.
  • Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee.

Allergen Information

Non-GMO | Gluten-free | Dairy-free | Sugar-free | Allergen-free | No fillers | No preservatives | Vegetarian

IngredientAmount Per Serving% Daily Value
Serving Size1 Capsule†
Servings Per Container14
Asafetida oleo-gum-resin extract††250 mg**
A Proprietary Enzyme Blend of: Lactase, Protease, Amylase, Lipase & Cellulase200 mg**
Milk thistle (Silybum marianum) seed extract80 mg**
Heat-treated Bifidobacterium longum subsp. longum CECT7347 (ES1)25 mg**
**Daily Value not established.

Other Ingredients: Capsule [hydroxypropylmethylcellulose, water, sorbitol, silicon dioxide, and sodium copper chlorophyllin (color)], microcrystalline cellulose, magnesium stearate (vegetable), and silicon dioxide.

Take one capsule daily with the evening meal. A second capsule may be taken with a separate main meal, if needed or as directed by a healthcare practitioner.

Dry Place

  • Discontinue use and consult your healthcare practitioner if stomach discomfort occurs following administration. Do not use if you have a current peptic

  • or duodenal ulcer. Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding. If you are taking anti-diabetic medications, consult your healthcare practitioner before use. Keep out of the reach of children.

Frequently bought together

Frequently Asked Questions

Your gut and brain are in constant communication through the gut-brain axis — a signaling network that connects your digestive system to your central nervous system. When digestion is incomplete or your gut microbiome is out of balance, communication can trigger discomfort, restlessness, and disrupted sleep. Supporting digestion at night helps keep that signaling pathway calm, so your body can focus on rest rather than processing a backlog. * UltraFlora® Night Rest & Digest is formulated specifically to support that connection.

Your body shifts into "rest and digest" mode at night, meaning your parasympathetic nervous system prioritizes internal repair and digestion over external activity. Taking digestive enzymes before bed puts support where your body is already focused — helping break down food from your evening meal so you wake up feeling light and comfortable rather than heavy or bloated. * That's exactly what UltraFlora® Night Rest & Digest is designed to do.

Postbiotics are beneficial compounds produced when probiotics break down and ferment food in your gut. Unlike probiotics, which are live bacteria, postbiotics are stable, shelf-ready compounds that support gut barrier function, reduce digestive discomfort, and help maintain a balanced gut environment. * If you’re ready for a postbiotic formula with targeted gut support, UltraFlora® Night Rest & Digest does that without needing to rely on live cultures alone.

Yes. Nighttime bloating is often caused by undigested food fermenting in the gut, producing gas that builds up while you sleep. Digestive enzymes help break down proteins, fats, and carbohydrates more completely before they reach the colon, reducing the fuel available for gas-producing bacteria. * Try it risk-free with our 60-day money-back guarantee.

Digestive enzymes don't directly cause sleep, but they can support the conditions that make restful sleep easier. When your body isn't working overtime to process undigested food, you're less likely to experience the nighttime bloating, gas, or discomfort that disrupts sleep. UltraFlora® Night Rest & Digest combines digestive enzymes with botanicals that support the gut-brain axis — the communication network between your digestive system and your brain that influences how well you rest. *

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