SPM Active® One Daily
Eases soreness and supports joint health in as little as 2 weeks.*
New to Metagenics? Get 15% off your first order + free shipping! Auto-applied at checkout.
Select Container Size
Why you'll love SPM Active® One Daily
Your body naturally produces specialized pro-resolving mediators (SPMs) to ease soreness and support recovery, but SPM levels decline with age. SPM Active® One Daily replenishes what your body needs*: concentrated SPMs derived from omega-3 fish oil, formulated to target the root causes of soreness.
The result is less joint discomfort, faster bounce-back after activity, and support for long-term joint health*, all in one convenient softgel per day. Feel less sore in as little as 2 weeks.*†
- Targets soreness at the source, not just the symptoms*
- 36% felt less sore in 2 weeks; 81% less joint discomfort at 3 months*†
- Eases everyday soreness and supports joint health*
- Helps you bounce back after physical activity or daily stress*
- Convenient once-daily dose—just one softgel per day
- Next-generation fish oil with concentrated SPMs
- Friend of the Sea Certified ensuring responsible sourcing and environmental protection
- Satisfaction Guaranteed: Love it within 60 days or your money back
The Science Inside SPM Active® One Daily
Your body naturally produces specialized pro-resolving mediators (SPMs) to help ease soreness and support recovery. But over time, our SPM levels drop and muscle and joint discomfort start to add up.*
SPM Active® One Daily gives your body more of what it needs in just one softgel per day. These natural compounds from omega-3 fish oil help your body ease soreness rather than simply masking symptoms.*
What to expect with consistent use:
- 14 days: Helps ease everyday soreness so you can move more freely.*†
- 1 month: 77% of people felt less joint discomfort.†
- 8 weeks: Improvements in mood, mental clarity, stress, and fatigue.*
Specialized Pro-Resolving Mediators (SPMs) — Natural compounds that help your body target the root cause of soreness and support lasting joint health.*
How Are SPMs Different from Traditional EPA/DHA Omega-3 Fish Oils?
Most fish oils supply EPA and DHA, which your body then has to convert into SPMs. SPM Active® One Daily skips that step. It delivers bioactive omega oils with specialized pro-resolving mediators (SPMs) already pre-converted and ready to work, supporting your body's natural recovery process more efficiently.*
The result: targeted relief that helps ease minor joint discomfort, support immune balance, and speed up recovery after physical stress or exercise.*
SPM Active® One Daily is clinically tested to help you feel less sore in as little as 14 days.† As we age, natural SPM production declines. This formula helps replenish those levels so your body can bounce back.*
Third-Party Tested. Practitioner Trusted.
For over 40 years, Metagenics® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:
- Produced in GMP and NSF-certified facilities to meet the highest quality standards.
- Science-backed: We perform +200K quality tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
- Third-party Tested: All our products are independently verified for purity, potency, & safety.
- Metagenics® is the #1 Doctor-Recommended Professional Supplement Brand★ trusted by 50,000 healthcare practitioners.
- Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly, and with purpose.
- Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee.
Allergen Information
Contains fish | Non-GMO | Gluten-Free | Sugar-Free | Lactose-Free
†Based on loading dose with 2g SPM Active daily for 6 weeks
††36% of clinical study participants reported decreased soreness and discomfort after 2 weeks of supplementation with 1.5 g SPM Active daily. Callan N, et al. J Transl Med. 2020;18(1):401.
| Amount Per Serving | % Daily Value | ||
|---|---|---|---|
| Serving Size | 1 Softgel | ||
| Servings Per Container | 14 | ||
| Calories | 10 | ||
| Total Fat | 1 g | 1%** | |
| Cholesterol | <5 mg | <2% | |
| Active Fractionated Marine Lipid Concentrate† | 1 g | *** | |
| SPM content standardized to | |||
| 18-hydroxy-eicosapentaenoic acid (18-HEPE) | |||
| 17-hydroxy-docosahexaenoic acid (17-HDHA) | |||
| 14-hydroxy-docosahexaenoic acid (14-HDHA) | |||
| **Percent Daily Values are based on a 2,000 calorie diet. | |||
| ***Daily Value not established. | |||
| †US Patents 11,077,083 and 11,077,084 |
Ingredients: Fractionated marine lipid concentrate [fish oil (anchovy, sardine, and mackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin, and water), and silica. Contains: Fish (anchovy, sardine, and mackerel).
SKU: SPMAD14
Take one softgel once daily or as directed by your healthcare practitioner.
Dry Place or Refrigerate
Frequently bought together
Rapid Relief
Fast-acting, drug-free pain relief for muscle and joint soreness*
4.2SPM Active®
Targets the root causes of body soreness*
4.5
Vitamin D3 5000 + K
Supports strong bones, heart, and immune health
4.6
New to Metagenics? Get 15% off your first order + free shipping! Auto-applied at checkout.
Select Container Size
Why you'll love SPM Active® One Daily
Your body naturally produces specialized pro-resolving mediators (SPMs) to ease soreness and support recovery, but SPM levels decline with age. SPM Active® One Daily replenishes what your body needs*: concentrated SPMs derived from omega-3 fish oil, formulated to target the root causes of soreness.
The result is less joint discomfort, faster bounce-back after activity, and support for long-term joint health*, all in one convenient softgel per day. Feel less sore in as little as 2 weeks.*†
- Targets soreness at the source, not just the symptoms*
- 36% felt less sore in 2 weeks; 81% less joint discomfort at 3 months*†
- Eases everyday soreness and supports joint health*
- Helps you bounce back after physical activity or daily stress*
- Convenient once-daily dose—just one softgel per day
- Next-generation fish oil with concentrated SPMs
- Friend of the Sea Certified ensuring responsible sourcing and environmental protection
- Satisfaction Guaranteed: Love it within 60 days or your money back
The Science Inside SPM Active® One Daily
Your body naturally produces specialized pro-resolving mediators (SPMs) to help ease soreness and support recovery. But over time, our SPM levels drop and muscle and joint discomfort start to add up.*
SPM Active® One Daily gives your body more of what it needs in just one softgel per day. These natural compounds from omega-3 fish oil help your body ease soreness rather than simply masking symptoms.*
What to expect with consistent use:
- 14 days: Helps ease everyday soreness so you can move more freely.*†
- 1 month: 77% of people felt less joint discomfort.†
- 8 weeks: Improvements in mood, mental clarity, stress, and fatigue.*
Specialized Pro-Resolving Mediators (SPMs) — Natural compounds that help your body target the root cause of soreness and support lasting joint health.*
How Are SPMs Different from Traditional EPA/DHA Omega-3 Fish Oils?
Most fish oils supply EPA and DHA, which your body then has to convert into SPMs. SPM Active® One Daily skips that step. It delivers bioactive omega oils with specialized pro-resolving mediators (SPMs) already pre-converted and ready to work, supporting your body's natural recovery process more efficiently.*
The result: targeted relief that helps ease minor joint discomfort, support immune balance, and speed up recovery after physical stress or exercise.*
SPM Active® One Daily is clinically tested to help you feel less sore in as little as 14 days.† As we age, natural SPM production declines. This formula helps replenish those levels so your body can bounce back.*
Third-Party Tested. Practitioner Trusted.
For over 40 years, Metagenics® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:
- Produced in GMP and NSF-certified facilities to meet the highest quality standards.
- Science-backed: We perform +200K quality tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
- Third-party Tested: All our products are independently verified for purity, potency, & safety.
- Metagenics® is the #1 Doctor-Recommended Professional Supplement Brand★ trusted by 50,000 healthcare practitioners.
- Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly, and with purpose.
- Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee.
Allergen Information
Contains fish | Non-GMO | Gluten-Free | Sugar-Free | Lactose-Free
†Based on loading dose with 2g SPM Active daily for 6 weeks
††36% of clinical study participants reported decreased soreness and discomfort after 2 weeks of supplementation with 1.5 g SPM Active daily. Callan N, et al. J Transl Med. 2020;18(1):401.
| Amount Per Serving | % Daily Value | ||
|---|---|---|---|
| Serving Size | 1 Softgel | ||
| Servings Per Container | 14 | ||
| Calories | 10 | ||
| Total Fat | 1 g | 1%** | |
| Cholesterol | <5 mg | <2% | |
| Active Fractionated Marine Lipid Concentrate† | 1 g | *** | |
| SPM content standardized to | |||
| 18-hydroxy-eicosapentaenoic acid (18-HEPE) | |||
| 17-hydroxy-docosahexaenoic acid (17-HDHA) | |||
| 14-hydroxy-docosahexaenoic acid (14-HDHA) | |||
| **Percent Daily Values are based on a 2,000 calorie diet. | |||
| ***Daily Value not established. | |||
| †US Patents 11,077,083 and 11,077,084 |
Ingredients: Fractionated marine lipid concentrate [fish oil (anchovy, sardine, and mackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin, and water), and silica. Contains: Fish (anchovy, sardine, and mackerel).
SKU: SPMAD14
Take one softgel once daily or as directed by your healthcare practitioner.
Dry Place or Refrigerate
Frequently bought together
Rapid Relief
Fast-acting, drug-free pain relief for muscle and joint soreness*
4.2SPM Active®
Targets the root causes of body soreness*
4.5Vitamin D3 5000 + K
Supports strong bones, heart, and immune health
4.6
