SPM Active®
Targets the root causes of body soreness*
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Why you'll love SPM Active®:
Get back to feeling like yourself. SPM Active® delivers specialized pro-resolving mediators (SPMs): concentrated nutrients from omega-3 fish oil that target the root causes of soreness, not just the symptoms. Clinical research showed a decrease in joint soreness and discomfort intensity in 2 weeks.*††
Whether it's joint discomfort, post-exercise recovery, or everyday aches, this SPM supplement helps your body bounce back so you can keep moving freely.
- Targets soreness at the source, not just the symptoms*
- 36% felt less sore in 2 weeks; 81% less joint discomfort at 3 months*†
- Eases everyday soreness and supports joint health*
- Helps you bounce back after physical activity or daily stress*
- Next-generation fish oil with concentrated SPMs
- Friend of the Sea Certified ensuring responsible sourcing and environmental protection
- Satisfaction Guaranteed: Love it within 60 days or your money back
Want a convenient single-softgel option? Try SPM Active One Daily.
The Science Inside SPM Active®
Your body naturally produces specialized pro-relieving mediators (SPMs) to help ease soreness and support recovery. But as we age, our SPM levels drop, and that's when muscle and joint discomfort start to add up.
SPM Active® gives your body more of what it needs. These natural compounds from omega-3 fish oil help your body ease soreness rather than simply masking symptoms.*
What to expect with consistent use:
- 14 days: Helps ease everyday soreness so you can move more freely.*†
- 1 month: 77% of people felt less joint discomfort.†
- 8 weeks: Improvements in mood, mental clarity, stress, and fatigue.*
Specialized Pro-Resolving Mediators (SPMs) — Natural compounds that help your body ease soreness and support lasting joint health.*
How Are SPMs Different from Traditional EPA/DHA Omega-3 Fish Oils?
While EPA and DHA fish oil supplements support foundational wellness by supplying essential fatty acids for overall health, SPM Active® is designed for targeted support. Derived from omega-3 fatty acids, it delivers bioactive specialized pro-resolving mediators (SPMs) that are already pre-converted, meaning they do not require the same metabolic conversion as traditional fish oil.* This allows SPM Active® to support your body's natural inflammation resolution pathways more efficiently, helping ease minor joint discomfort and support faster recovery after physical stress or exercise.*
Third-party tested. Practitioner trusted.
For over 40 years, Metagenics® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:
- Produced in GMP and NSF-certified facilities to meet the highest quality standards.
- Science-backed: We perform +200K quality tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
- Third-party Tested: All our products are independently verified for purity, potency, & safety.
- Metagenics® is the #1 Doctor-Recommended Professional Supplement Brand★ trusted by 50,000 healthcare practitioners.
- Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly, and with purpose.
- Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee..
What's Inside (and What's Not)
Contains fish | Non-GMO | Gluten-Free | Sugar-Free | Lactose-Free
| Ingredients | Amount Per Serving | % Daily Value |
|---|---|---|
| Serving Size | 2 Softgels | |
| Servings Per Container | 60 | |
| Calories | 10 | |
| Total Fat | 1 g | 1%* |
| Cholesterol | <5 mg | <2% |
| Active Fractionated Marine Lipid Concentrate† SPM content standardized to 18-hydroxy-eicosapentaenoic acid (18-HEPE) 17-hydroxy-docosahexaenoic acid (17-HDHA) and 14-hydroxy-docosahexaenoic acid (14-HDHA). | 1 g | ** |
Other Ingredients: Fractionated marine lipid concentrate [fish oil (anchovy, sardine, andmackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin,and water), and silica. Contains: Fish (anchovy, sardine, and mackerel).
SKU: SPMA60
Dosage: Take two softgels once daily or as directed by your healthcare practitioner. Best For: Adults seeking relief for body soreness and joint discomfort. If you are pregnant, nursing, or taking medication, consult your healthcare practitioner before use. Keep out of the reach of children. Safe for Daily Use: Safe and gentle for everyday use. Take two softgels per day.
Dry Place
†Based on loading dose with 2g SPM Active daily for 6 weeks
††36% of clinical study participants reported decreased soreness and discomfort after 2 weeks of supplementation with 1.5 g SPM Active daily. Callan N, et al. J Transl Med. 2020;18(1):401.
Frequently bought together
SPM Active® One Daily
Supports your body’s natural ability to recover from soreness and physical strain.*
4.5
OsteoVantiv®
Provides joint relief & supports joint flexibility.*
5.0SpectraZyme® Betaine HCI + Pepsin
Support for stomach acid discomfort.*
4.7
Select Container Size
Why you'll love SPM Active®:
Get back to feeling like yourself. SPM Active® delivers specialized pro-resolving mediators (SPMs): concentrated nutrients from omega-3 fish oil that target the root causes of soreness, not just the symptoms. Clinical research showed a decrease in joint soreness and discomfort intensity in 2 weeks.*††
Whether it's joint discomfort, post-exercise recovery, or everyday aches, this SPM supplement helps your body bounce back so you can keep moving freely.
- Targets soreness at the source, not just the symptoms*
- 36% felt less sore in 2 weeks; 81% less joint discomfort at 3 months*†
- Eases everyday soreness and supports joint health*
- Helps you bounce back after physical activity or daily stress*
- Next-generation fish oil with concentrated SPMs
- Friend of the Sea Certified ensuring responsible sourcing and environmental protection
- Satisfaction Guaranteed: Love it within 60 days or your money back
Want a convenient single-softgel option? Try SPM Active One Daily.
The Science Inside SPM Active®
Your body naturally produces specialized pro-relieving mediators (SPMs) to help ease soreness and support recovery. But as we age, our SPM levels drop, and that's when muscle and joint discomfort start to add up.
SPM Active® gives your body more of what it needs. These natural compounds from omega-3 fish oil help your body ease soreness rather than simply masking symptoms.*
What to expect with consistent use:
- 14 days: Helps ease everyday soreness so you can move more freely.*†
- 1 month: 77% of people felt less joint discomfort.†
- 8 weeks: Improvements in mood, mental clarity, stress, and fatigue.*
Specialized Pro-Resolving Mediators (SPMs) — Natural compounds that help your body ease soreness and support lasting joint health.*
How Are SPMs Different from Traditional EPA/DHA Omega-3 Fish Oils?
While EPA and DHA fish oil supplements support foundational wellness by supplying essential fatty acids for overall health, SPM Active® is designed for targeted support. Derived from omega-3 fatty acids, it delivers bioactive specialized pro-resolving mediators (SPMs) that are already pre-converted, meaning they do not require the same metabolic conversion as traditional fish oil.* This allows SPM Active® to support your body's natural inflammation resolution pathways more efficiently, helping ease minor joint discomfort and support faster recovery after physical stress or exercise.*
Third-party tested. Practitioner trusted.
For over 40 years, Metagenics® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:
- Produced in GMP and NSF-certified facilities to meet the highest quality standards.
- Science-backed: We perform +200K quality tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
- Third-party Tested: All our products are independently verified for purity, potency, & safety.
- Metagenics® is the #1 Doctor-Recommended Professional Supplement Brand★ trusted by 50,000 healthcare practitioners.
- Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly, and with purpose.
- Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee..
What's Inside (and What's Not)
Contains fish | Non-GMO | Gluten-Free | Sugar-Free | Lactose-Free
| Ingredients | Amount Per Serving | % Daily Value |
|---|---|---|
| Serving Size | 2 Softgels | |
| Servings Per Container | 60 | |
| Calories | 10 | |
| Total Fat | 1 g | 1%* |
| Cholesterol | <5 mg | <2% |
| Active Fractionated Marine Lipid Concentrate† SPM content standardized to 18-hydroxy-eicosapentaenoic acid (18-HEPE) 17-hydroxy-docosahexaenoic acid (17-HDHA) and 14-hydroxy-docosahexaenoic acid (14-HDHA). | 1 g | ** |
Other Ingredients: Fractionated marine lipid concentrate [fish oil (anchovy, sardine, andmackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin,and water), and silica. Contains: Fish (anchovy, sardine, and mackerel).
SKU: SPMA60
Dosage: Take two softgels once daily or as directed by your healthcare practitioner. Best For: Adults seeking relief for body soreness and joint discomfort. If you are pregnant, nursing, or taking medication, consult your healthcare practitioner before use. Keep out of the reach of children. Safe for Daily Use: Safe and gentle for everyday use. Take two softgels per day.
Dry Place
†Based on loading dose with 2g SPM Active daily for 6 weeks
††36% of clinical study participants reported decreased soreness and discomfort after 2 weeks of supplementation with 1.5 g SPM Active daily. Callan N, et al. J Transl Med. 2020;18(1):401.
Frequently bought together
SPM Active® One Daily
Supports your body’s natural ability to recover from soreness and physical strain.*
4.5OsteoVantiv®
Provides joint relief & supports joint flexibility.*
5.0SpectraZyme® Betaine HCI + Pepsin
Support for stomach acid discomfort.*
4.7
