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Creatine UP®

More strength. More muscle. Powered by creatine, betaine and taurine to fuel performance.*

Protein & Sports Nutrition
Brain & Cognitive Health
Essential Wellness

New to Metagenics? Get 15% off your first order + free shipping! Auto-applied at checkout.

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Why you'll love Creatine UP®

Creatine UP® is a 3-in-1 muscle recovery supplement that combines creatine monohydrate with two key muscle-support ingredients, betaine and taurine, to fuel your workouts and support your recovery.

Most creatine products stop at creatine. Creatine UP® goes further, pairing it with betaine and taurine to help your muscles work harder, stay hydrated, and bounce back faster after every session.*

Lift more. Train longer. Recover faster.

  • Powered by 3 ingredients: Creatine monohydrate, betaine, and taurine
  • Increases muscle strength and power output*
  • Supports ATP recovery for repeated bursts of energy*
  • Promotes lean muscle growth and endurance*
  • Enhances high-intensity training performance and helps delay fatigue*
  • Helps support muscle mass, hydration, and faster recovery*
  • Satisfaction Guaranteed: Love it within 60 days or your money back

The Science Inside

Creatine UP® combines three clinically studied ingredients that work together to support performance and recovery at the cellular level.*

Micronized Creatine Monohydrate (5 g per serving) — When you exercise, your body burns through ATP, your main energy source, fast. Creatine helps refill those energy stores so you can keep pushing through lifts, sprints, and hard sets. Used consistently with exercise, it also supports lean muscle growth and improved strength.*

Betaine (as betaine anhydrous, 1 g per serving) — Betaine helps your muscle cells hold onto water and stay hydrated during intense effort. This supports endurance and helps protect your performance when training gets tough.*

Taurine (0.75 g per serving) — Taurine supports healthy muscle function and helps your muscles resist fatigue. Paired with betaine, it works to keep you performing at your best.*


Triple tested. Practitioner trusted.

For over 40 years, Metagenics® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:

  • Produced in GMP certified facilities to meet the highest quality standards.
  • Science-backed: We perform +200K quality tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
  • Triple tested: All our products are verified for identity, purity, strength, and stability at three levels of production: ingredient, formula, and encapsulation.
  • Metagenics is the #1 Doctor-Recommended Professional Supplement Brand trusted by 50,000 healthcare practitioners.
  • Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly, and with purpose.
  • Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee.

Allergen Info

Non-GMO | Gluten-Free | Vegetarian | Sugar-Free | Dairy-Free | Soy-Free

IngredientsAmount Per Serving% Daily Value
Serving Size1 Scoop (7.3 g)
Servings Per Container30
Calories30
Creatine Monohydrate5 g*
Betaine (as betaine anhydrous)1 g*
Taurine0.75 g*


SKU: CREUP60

Mix 1 scoop (7.3 g) daily with 8 oz of water or your beverage of choice. For best results, take Creatine UP® 30 minutes before or right after exercise. Pairs well with a recovery supplement such as Perfect Protein (available in whey and vegan formulas). To maximize results, take 4 servings daily for the first week, then 1–2 servings daily after that. On rest days, take 1–2 servings daily with a meal or as directed by a trainer, coach, or healthcare professional.

Dry Place

  • Not for use in patients with severe liver, kidney, cardiovascular disease, or bipolar disorder.

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Metagenics delivers precision-crafted formulas to support your health—because true wellness starts with integrity, balance, & expertise.
Protein & Sports Nutrition
Brain & Cognitive Health
Essential Wellness

New to Metagenics? Get 15% off your first order + free shipping! Auto-applied at checkout.

Select Container Size

Why you'll love Creatine UP®

Creatine UP® is a 3-in-1 muscle recovery supplement that combines creatine monohydrate with two key muscle-support ingredients, betaine and taurine, to fuel your workouts and support your recovery.

Most creatine products stop at creatine. Creatine UP® goes further, pairing it with betaine and taurine to help your muscles work harder, stay hydrated, and bounce back faster after every session.*

Lift more. Train longer. Recover faster.

  • Powered by 3 ingredients: Creatine monohydrate, betaine, and taurine
  • Increases muscle strength and power output*
  • Supports ATP recovery for repeated bursts of energy*
  • Promotes lean muscle growth and endurance*
  • Enhances high-intensity training performance and helps delay fatigue*
  • Helps support muscle mass, hydration, and faster recovery*
  • Satisfaction Guaranteed: Love it within 60 days or your money back

The Science Inside

Creatine UP® combines three clinically studied ingredients that work together to support performance and recovery at the cellular level.*

Micronized Creatine Monohydrate (5 g per serving) — When you exercise, your body burns through ATP, your main energy source, fast. Creatine helps refill those energy stores so you can keep pushing through lifts, sprints, and hard sets. Used consistently with exercise, it also supports lean muscle growth and improved strength.*

Betaine (as betaine anhydrous, 1 g per serving) — Betaine helps your muscle cells hold onto water and stay hydrated during intense effort. This supports endurance and helps protect your performance when training gets tough.*

Taurine (0.75 g per serving) — Taurine supports healthy muscle function and helps your muscles resist fatigue. Paired with betaine, it works to keep you performing at your best.*


Triple tested. Practitioner trusted.

For over 40 years, Metagenics® has led innovation in health supplements, exceeding industry standards for transparency and accountability. We guarantee that what’s on the label is what’s in the bottle, and that commitment is why we’re trusted by more than 50,000 healthcare providers worldwide. This, and all our formulas are also:

  • Produced in GMP certified facilities to meet the highest quality standards.
  • Science-backed: We perform +200K quality tests annually, from ingredient sourcing to finished product, for accuracy and consistency.
  • Triple tested: All our products are verified for identity, purity, strength, and stability at three levels of production: ingredient, formula, and encapsulation.
  • Metagenics is the #1 Doctor-Recommended Professional Supplement Brand trusted by 50,000 healthcare practitioners.
  • Environmentally Responsible: As a registered B-Corp, sustainability matters; all our products are made ethically, responsibly, and with purpose.
  • Risk Free: Every purchase is backed by our 60-Day Money Back Guarantee.

Allergen Info

Non-GMO | Gluten-Free | Vegetarian | Sugar-Free | Dairy-Free | Soy-Free

IngredientsAmount Per Serving% Daily Value
Serving Size1 Scoop (7.3 g)
Servings Per Container30
Calories30
Creatine Monohydrate5 g*
Betaine (as betaine anhydrous)1 g*
Taurine0.75 g*


SKU: CREUP60

Mix 1 scoop (7.3 g) daily with 8 oz of water or your beverage of choice. For best results, take Creatine UP® 30 minutes before or right after exercise. Pairs well with a recovery supplement such as Perfect Protein (available in whey and vegan formulas). To maximize results, take 4 servings daily for the first week, then 1–2 servings daily after that. On rest days, take 1–2 servings daily with a meal or as directed by a trainer, coach, or healthcare professional.

Dry Place

  • Not for use in patients with severe liver, kidney, cardiovascular disease, or bipolar disorder.

Frequently bought together

Frequently Asked Questions

Creatine UP® is a 3-in-1 muscle recovery supplement that combines creatine monohydrate, betaine, and taurine to increase muscle strength, support energy recovery, and fuel high-intensity performance.* Creatine helps refill your body's energy stores so you can push harder in every workout. Try it today backed by our 60-Day Money Back Guarantee.

Most people start noticing improvements in strength and performance within 1–2 weeks of daily use, especially when following the loading protocol (4 servings daily for the first week).* For best results, take Creatine UP® every day alongside regular exercise.

Creatine supports energy production throughout the body, including the brain.* Research suggests it may help maintain mental clarity and focus during demanding tasks or when you're running low on sleep.* Try Creatine UP® today, backed by our 60-Day Money Back Guarantee.

Mix 1 scoop (7.3 g) with 8 oz of water or any drink you like. Take it 30 minutes before exercise or right after, alongside a recovery supplement like Perfect Protein. For best results, take 4 servings daily for the first week, then 1–2 servings daily after that.

Yes. Creatine UP® is Non-GMO, Gluten-Free, Vegetarian, Sugar-Free, Dairy-Free, and Soy-Free, so it works for a wide range of dietary needs. Try it risk-free with our 60-Day Money Back Guarantee.

We stand behind every product. If you don't love Creatine UP® within 60 days, we'll refund your purchase — no questions asked. Learn more about our 60-Day Money Back Guarantee.

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