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Calm Mood & Stress Resilience for Women by Dr. Melissa Blake, ND

Designed for women stuck in stress mode, this doctor-curated supplement stack supports mood, brain health, and gut–brain communication for more calm & focus.

Save more when you bundle versus buying each supplement separately!

Why you’ll love the Calm & Stress Resilience Stack for Women

This stack helps women stuck in “stress mode” restore balance to the nervous system through three key pathways:

  • Mood: Supports healthy serotonin and dopamine activity with targeted amino acids and cofactors.
  • Mind: Delivers clinical levels of omega-3 fatty acids to reduce neuroinflammation.
  • Microbiome: Restores gut diversity and strengthens gut–brain communication.

    These nutrients address the biochemical roots of anxiety and fatigue so women can feel calmer, more focused, and resilient again. Developed by Dr. Melissa Blake, a naturopathic doctor who specializes in women’s health, this protocol blends science with simplicity. Join the thousands of women who’ve felt the shift, and start your reset today.


The Science Inside This Supplement Stack

1) SeroSyn™ - Supports serotonin and dopamine pathways to promote:

  • Balanced mood
  • Mental focus
  • Emotional well-being

2) OmegaGenics® Fish Oil EPA-DHA 1000 mg - Delivers high-potency omega-3s to:

  • Reduce inflammation
  • Support mood stability
  • Promote cognitive clarity under stress

3) UltraFlora® Complete Women’s Probiotic – Made by women, for women, this comprehensive 5-in-1 women’s probiotic blend helps:

  • Improve gut-brain communication
  • Promote digestive comfort
  • Support mood regulation

    While each product supports a different system (mood, mind, and microbiome), their combined impact helps regulate the full stress response, unlocking steadier energy, emotional balance, and digestive ease.


Key Ingredients Explained

  • L-Theanine + 5-HTP are amino acids that help you stay calm and focused by supporting serotonin and GABA balance*
  • EPA + DHA from fish oil nourish your brain to ease tension and inflammation, helping you feel more centered and steady*
  • 5 clinically studied probiotic strains designed specifically for women to soothe your mind and promote a calmer, more balanced mood and gut*

Science-backed & third-party tested

The formulas in the Calm Mood & Stress Resilience Stack are supported by over 400 clinical studies, over 100 human clinical trials, and are manufactured in NSF-certified facilities. Every batch is third-party tested for purity, potency, and safety. As the #1 doctor-recommended professional supplement brand, Metagenics is trusted by over 50,000 healthcare providers.

  • Clinically studied ingredients
  • Third-party tested for quality & efficacy
  • Guaranteed purity & potency
  • Doctor-trusted and recommended
  • Backed by over 2,000 glowing reviews and a 4.7-star rating on Amazon
  • Over 25M bottles sold worldwide in the last year
  • Risk-Free: Try risk-free with our 60-day money back guarantee

Allergen Info

Non-GMO | Gluten-Free | Sugar-Free | Dairy-Free | Soy-Free | Corn-Free | Egg- Free | No Artificial Flavors | Contains Live Probiotics | Contains Fish

SeroSyn™

IngredientsAmount Per Serving% Daily Value
Serving Size1 Capsule†
Servings Per Container90
Vitamin B6 (as pyridoxine HCl)10 mg588%
Folate (as calcium L-5-methyltetrahydrofolate)††555 mcg139%
Vitamin B12 (as methylcobalamin)250 mcg10,417%
Chinese Skullcap (Scutellaria baicalensis) Root Extract [standardized to 30% (60 mg) flavones]200 mg*
L-5-Hydroxytryptophan (L-5-HTP)100 mg*
Asian Ginseng (Panax ginseng) Root Extract [standardized to 8% (8 mg) ginsenosides]100 mg*
L-Theanine80 mg*

Other Ingredients: Capsule (hydroxypropylmethylcellulose), microcrystalline cellulose, silica, and stearic acid (vegetable).



SKU: SERO90

UltraFlora® Complete Women's Probiotic

IngredientAmount
Serving Size1 Capsule†
Servings Per Container30
A Probiotic Blend of: Lactobacillus acidophilus (DDS-1™)†† (10 billion CFU)††† Lactiplantibacillus plantarum (Lpla33™)†† (10 billion CFU)††† Lactobacillus reuteri (RC-14®)†† (1 billion CFU)††† Lactobacillus rhamnosus (GR-1®)†† (1 billion CFU)††† Bifidobacterium animalis subsp. lactis (BB-12®)†† (1 billion CFU)†††226 mg

**Daily Value not established.

Other Ingredients: Microcrystalline cellulose, capsule (hydroxypropylmethylcellulose), silicon dioxide, and magnesium stearate (vegetable).



SKU: UFWC30

OmegaGenics® Fish Oil EPA-DHA 1000 mg

IngredientsAmount Per Serving% Daily Value
Serving Size1 Softgel
Servings Per Container60
Calories15
Total Fat1.5 g2%*
Cholesterol5 mg2%
Marine Lipid Concentrate1.4 g**
EPA (Eicosapentaenoic acid triglyceride)710 mg**
DHA (Docosahexaenoic acid triglyceride)290 mg**
Other Omega-3 Fatty Acid Triglycerides100 mg**

Other Ingredients: Marine lipid concentrate [fish (anchovy, sardine, and mackerel) oil], softgel shell (gelatin, glycerin, water), contains 2 percent or less of natural lemon flavor, mixed tocopherols (antioxidant), rosemary extract, and ascorbyl palmitate (antioxidant). Contains: Fish (anchovy, sardine, and mackerel).



SKU: EPATG

SeroSyn™

Directions: Take one capsule three times daily with food or as directed by your healthcare practitioner.

UltraFlora® Complete Women's Probiotic

Take one capsule once daily or as directed by your healthcare practitioner.

OmegaGenics® Fish Oil EPA-DHA 1000 mg

Directions: Take one softgel up to three times daily with food or as directed by your healthcare practitioner.

SeroSyn™

Dry Place

OmegaGenics® Fish Oil EPA-DHA 1000 mg

Dry Place

SeroSyn™

Not recommended for those under 18 years of age. If taking antidepressant medication, particularly antidepressants such as MAO inhibitors or selective serotonin reuptake inhibitors (SSRIs), avoid use. If you have a medical condition—including symptomatic gastrointestinal disorders, or are taking medication—including over-the-counter cold medicine and high blood pressure medicines, consult your healthcare practitioner before use. Use with caution when driving or operating machinery, may cause drowsiness. Keep out of the reach of children.

OmegaGenics® Fish Oil EPA-DHA 1000 mg

Consult your healthcare practitioner if pregnant, nursing, or taking medications. Keep out of the reach of children.

SeroSyn™

  • Do not use if pregnant or nursing.

Dr. Melissa Blake is a naturopathic doctor with almost two decades of clinical experience helping women 35+ reclaim their mental, emotional, and physical health. Her approach blends functional medicine, naturopathy, and behavioral psychology to address the root causes of mood imbalance, which are often found in the gut, hormones, and stress response. Dr. Blake has partnered with Metagenics for over 15 years to provide evidence-based, targeted supplementation to her patients

In This Stack

  • SeroSyn™

    Supports calmness and relaxation.*

    5.0
    SeroSyn™
  • OmegaGenics® Fish Oil EPA-DHA 1000 mg

    5-in-1 omega-3 fish oil Supplement for heart, eye, immune, bone, & muscle health*

    4.7

    Best Seller

    OmegaGenics® Fish Oil EPA-DHA 1000 mg
The Science That Creates Balance®
Metagenics Special Ingredient Image
Metagenics delivers precision-crafted formulas to support your health—because true wellness starts with integrity, balance, & expertise.

Save more when you bundle versus buying each supplement separately!

Why you’ll love the Calm & Stress Resilience Stack for Women

This stack helps women stuck in “stress mode” restore balance to the nervous system through three key pathways:

  • Mood: Supports healthy serotonin and dopamine activity with targeted amino acids and cofactors.
  • Mind: Delivers clinical levels of omega-3 fatty acids to reduce neuroinflammation.
  • Microbiome: Restores gut diversity and strengthens gut–brain communication.

    These nutrients address the biochemical roots of anxiety and fatigue so women can feel calmer, more focused, and resilient again. Developed by Dr. Melissa Blake, a naturopathic doctor who specializes in women’s health, this protocol blends science with simplicity. Join the thousands of women who’ve felt the shift, and start your reset today.


The Science Inside This Supplement Stack

1) SeroSyn™ - Supports serotonin and dopamine pathways to promote:

  • Balanced mood
  • Mental focus
  • Emotional well-being

2) OmegaGenics® Fish Oil EPA-DHA 1000 mg - Delivers high-potency omega-3s to:

  • Reduce inflammation
  • Support mood stability
  • Promote cognitive clarity under stress

3) UltraFlora® Complete Women’s Probiotic – Made by women, for women, this comprehensive 5-in-1 women’s probiotic blend helps:

  • Improve gut-brain communication
  • Promote digestive comfort
  • Support mood regulation

    While each product supports a different system (mood, mind, and microbiome), their combined impact helps regulate the full stress response, unlocking steadier energy, emotional balance, and digestive ease.


Key Ingredients Explained

  • L-Theanine + 5-HTP are amino acids that help you stay calm and focused by supporting serotonin and GABA balance*
  • EPA + DHA from fish oil nourish your brain to ease tension and inflammation, helping you feel more centered and steady*
  • 5 clinically studied probiotic strains designed specifically for women to soothe your mind and promote a calmer, more balanced mood and gut*

Science-backed & third-party tested

The formulas in the Calm Mood & Stress Resilience Stack are supported by over 400 clinical studies, over 100 human clinical trials, and are manufactured in NSF-certified facilities. Every batch is third-party tested for purity, potency, and safety. As the #1 doctor-recommended professional supplement brand, Metagenics is trusted by over 50,000 healthcare providers.

  • Clinically studied ingredients
  • Third-party tested for quality & efficacy
  • Guaranteed purity & potency
  • Doctor-trusted and recommended
  • Backed by over 2,000 glowing reviews and a 4.7-star rating on Amazon
  • Over 25M bottles sold worldwide in the last year
  • Risk-Free: Try risk-free with our 60-day money back guarantee

Allergen Info

Non-GMO | Gluten-Free | Sugar-Free | Dairy-Free | Soy-Free | Corn-Free | Egg- Free | No Artificial Flavors | Contains Live Probiotics | Contains Fish

SeroSyn™

IngredientsAmount Per Serving% Daily Value
Serving Size1 Capsule†
Servings Per Container90
Vitamin B6 (as pyridoxine HCl)10 mg588%
Folate (as calcium L-5-methyltetrahydrofolate)††555 mcg139%
Vitamin B12 (as methylcobalamin)250 mcg10,417%
Chinese Skullcap (Scutellaria baicalensis) Root Extract [standardized to 30% (60 mg) flavones]200 mg*
L-5-Hydroxytryptophan (L-5-HTP)100 mg*
Asian Ginseng (Panax ginseng) Root Extract [standardized to 8% (8 mg) ginsenosides]100 mg*
L-Theanine80 mg*

Other Ingredients: Capsule (hydroxypropylmethylcellulose), microcrystalline cellulose, silica, and stearic acid (vegetable).



SKU: SERO90

UltraFlora® Complete Women's Probiotic

IngredientAmount
Serving Size1 Capsule†
Servings Per Container30
A Probiotic Blend of: Lactobacillus acidophilus (DDS-1™)†† (10 billion CFU)††† Lactiplantibacillus plantarum (Lpla33™)†† (10 billion CFU)††† Lactobacillus reuteri (RC-14®)†† (1 billion CFU)††† Lactobacillus rhamnosus (GR-1®)†† (1 billion CFU)††† Bifidobacterium animalis subsp. lactis (BB-12®)†† (1 billion CFU)†††226 mg

**Daily Value not established.

Other Ingredients: Microcrystalline cellulose, capsule (hydroxypropylmethylcellulose), silicon dioxide, and magnesium stearate (vegetable).



SKU: UFWC30

OmegaGenics® Fish Oil EPA-DHA 1000 mg

IngredientsAmount Per Serving% Daily Value
Serving Size1 Softgel
Servings Per Container60
Calories15
Total Fat1.5 g2%*
Cholesterol5 mg2%
Marine Lipid Concentrate1.4 g**
EPA (Eicosapentaenoic acid triglyceride)710 mg**
DHA (Docosahexaenoic acid triglyceride)290 mg**
Other Omega-3 Fatty Acid Triglycerides100 mg**

Other Ingredients: Marine lipid concentrate [fish (anchovy, sardine, and mackerel) oil], softgel shell (gelatin, glycerin, water), contains 2 percent or less of natural lemon flavor, mixed tocopherols (antioxidant), rosemary extract, and ascorbyl palmitate (antioxidant). Contains: Fish (anchovy, sardine, and mackerel).



SKU: EPATG

SeroSyn™

Directions: Take one capsule three times daily with food or as directed by your healthcare practitioner.

UltraFlora® Complete Women's Probiotic

Take one capsule once daily or as directed by your healthcare practitioner.

OmegaGenics® Fish Oil EPA-DHA 1000 mg

Directions: Take one softgel up to three times daily with food or as directed by your healthcare practitioner.

SeroSyn™

Dry Place

OmegaGenics® Fish Oil EPA-DHA 1000 mg

Dry Place

SeroSyn™

Not recommended for those under 18 years of age. If taking antidepressant medication, particularly antidepressants such as MAO inhibitors or selective serotonin reuptake inhibitors (SSRIs), avoid use. If you have a medical condition—including symptomatic gastrointestinal disorders, or are taking medication—including over-the-counter cold medicine and high blood pressure medicines, consult your healthcare practitioner before use. Use with caution when driving or operating machinery, may cause drowsiness. Keep out of the reach of children.

OmegaGenics® Fish Oil EPA-DHA 1000 mg

Consult your healthcare practitioner if pregnant, nursing, or taking medications. Keep out of the reach of children.

SeroSyn™

  • Do not use if pregnant or nursing.

Dr. Melissa Blake is a naturopathic doctor with almost two decades of clinical experience helping women 35+ reclaim their mental, emotional, and physical health. Her approach blends functional medicine, naturopathy, and behavioral psychology to address the root causes of mood imbalance, which are often found in the gut, hormones, and stress response. Dr. Blake has partnered with Metagenics for over 15 years to provide evidence-based, targeted supplementation to her patients

In This Stack

Frequently Asked Questions

This stack is designed for those caught in a constant state of stress or emotional overwhelm. It’s especially supportive for women 35+ who notice mood swings, anxious tension, or digestive changes when life feels demanding.

Each product targets a key piece of the stress puzzle. 

Serosyn nourishes neurotransmitters that regulate mood and focus.  OmegaGenics EPA-DHA 1000 reduces inflammation and supports brain cell communication.  UltraFlora Women’s Complete restores gut-brain balance, easing the digestive tension that often accompanies chronic stress. 

Together, they address mood, mind, and microbiome to help reset the stress response from multiple angles.

Most women notice a sense of calm and clearer focus within 2–4 weeks of consistent use. Over 6–8 weeks, many experience steadier energy, fewer anxious thoughts, and improved digestion. These results build over time, especially when paired with good sleep, hydration, and daily movement.

Take Serosyn morning and mid-afternoon, OmegaGenics with meals, and UltraFlora daily. Consistency matters more than timing. Aim for daily use over 6–8 weeks, then evaluate improvements.

This Calm Mood & Stress Resilience for Women supports the core systems that regulate mood and stress, helping women move from tension and fatigue to a sense of calm focus. It’s a practical, effective way to rebuild resilience and feel balanced again.

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